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WFH 2014 World Congress

 

11-15 May 2014 Melbourne
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Discussion forum - WFH 2014 World Congress
    Topic - Inhibitors, Pathogenesis, Prevention and Treatment

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Poster: 35
Visits: 73
Title: Selection and characterization of single-chain variable antibody fragments (scFvs) specific for anti-FVIII antibodies
Authors: Kerstin Brettschneider , A. Naumann, J. Kahle, S. Neimanis, D. Schwabe, C. Heller, T. Klingebiel, C. Knigs
Centre: Clinical and Molecular Hemostasis, Department of Pediatrics, University Hospital Frankfurt, Frankfurt am Main

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SELECTION AND CHARACTERIZATION OF SINGLE-CHAIN VARIABLE ANTIBODY FRAGMENTS (SCFVS) SPECIFIC FOR ANTI-FVIII ANTIBODIES

Kerstin Brettschneider
Thread initiator
Subspeciality
Reg: 4/22/2014 7:43:00 PM
Comment# 1
The development of inhibitory allo-antibodies against coagulation factor VIII (FVIII) is currently the most serious complication for hemophilia A patients, who undergo FVIII replacement therapy. The aim of this project is to elucidate the capacity of single chain variable antibody fragments (scFvs) for neutralization of inhibitory anti-FVIII antibodies (FVIII inhibitors). Phage display technology was applied to select scFvs for strongly inhibitory murine monoclonal anti-FVIII antibodies (mAbs) from synthetic libraries. As the majority of inhibitory mAbs are directed against the A2 or C2 domain of FVIII, anti-A2 and anti-C2 mAbs were used as targets. Affinity selection led to the identification of several specific, potential anti-idiotypic scFvs, which were further characterized.

Comment added on 4/22/2014 7:43:00 PM 
     
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Most viewed poster for this congress
Poster: 1
Visits: 2526
Title: A WEB SITE TO IMPROVE MANAGEMENT OF PATIENTS WITH INHERITED BLEEDING DISORDERS IN THE EMERGENCY DEPARTMENT: RESULTS AT 2 YEARS
Authors: Annarita Tagliaferri ,
Centre: Centro di Riferimento Regionale per la cura dellEmofilia

Poster most viewed in this topic
Poster: 63
Visits: 314
Title: A Phase III clinical trial of a mixture of plasma-derived factor VIIa and factor X (MC710) in hemophilia patients with inhibitors: hemostatic efficacy and safety
Authors: YUICHI SHINKODA ,
Centre: Kagoshima City Hospital


 








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